TITLE: “Large uncertainty in individual PRS estimation impacts PRS-based risk stratification.” ABSTRACT: Large-scale genome-wide association studies have enabled polygenic risk scores (PRS), which estimate the genetic value of an individual […]

TITLE: "Constructing a Functional Interactome from Published Work to Identify Underrepresented and Integrative Effects of Neuroinflammatory Cytokines on Neural Excitability." ABSTRACT: Maintaining normal excitability is a key function of our […]

TITLE: "Metabolic dependencies of ecDNA and HSR focal amplification modes and plasticity." ABSTRACT: The focal amplification (FA) of genes that support the uncontrolled growth and proliferation of cells (i.e., oncogenes) […]

TITLE: "DoubletCollection: An R package that integrates cutting-edge computational doublet-detection methods." ABSTRACT: The existence of doublets is a key confounder in single-cell RNA sequencing (scRNA-seq) data analysis. There are several […]

TITLE: “Applications of generalized additive models and copulas to single-cell RNAseq computational method development: PseudotimeDE and scDesign2” ABSTRACT: Part 1: PseudotimeDE: inference of differential gene expression along cell pseudotime with […]

TITLE: “Integrating single cell omics and deep phenotype data to discover genes underlying cardiometabolic disorders” ABSTRACT: Obesity predisposes to cardiometabolic disorders (CMDs), such as type 2 diabetes, multiple dyslipidemias, and […]

TITLE: "Is there a Quiescence Histone Code?" ABSTRACT: Many of the cells in our bodies are quiescent, that is, temporarily not dividing. Under certain physiological conditions such as during tissue repair […]

TITLE: “Model driven design and analysis of quantitative phenotype screens” ABSTRACT: Increasingly, CRISPR screens are coupled with flow cytometry (FACS) to sort cells and quantify the impact of genetic perturbations on a continuous […]