TITLE: "Distal mediator-enriched placental transcriptome-wide association studies reveal genetic mechanisms supporting the  Developmental Origins of Health and Disease." ABSTRACT: As the master regulator of the intrauterine environment, the placenta is core to the Developmental Origins of Health and Disease (DOHaD) but is understudied in large consortia of tissue-specific gene and trait regulation. We performed distal mediator-enriched transcriptome-wide […]

TITLE: "Clipper: p-value-free FDR control on high-throughput data from two conditions." ABSTRACT: High-throughput biological data analysis commonly involves identifying "interesting" features (e.g., genes, genomic regions, and proteins), whose values differ between two conditions, from numerous features measured simultaneously. The most widely-used criterion to ensure the analysis reliability is the false discovery rate (FDR). Existing bioinformatics […]

Associate Professor, UCLA Institute for Society and Genetics “TBD” Hosted by Paivi Pajukanta

TITLE: "Critical slowing down signals quasi-species extinction in an evolutionary model with environmental heterogeneity." ABSTRACT: Environmental heterogeneity can significantly affect the evolutionary dynamics of a population. A key parameter that determines the influence of heterogeneity is the migration rate--the rate at which organisms explore their heterogeneous environment. We study a model of a population which migrates between […]

TITLE: "Integrating metabolomics and fluxomics to study cancer metabolism in low glucose environments." ABSTRACT: Metabolomics and fluxomics are integral tools for quantitative metabolic analysis. By combining mass spectrometry, isotope tracing, and […]

Associate Professor, Department of Biochemistry and Biophysics, UCSF “TBD” Hosted by David Eisenberg

TITLE:“Longitudinal phenotyping of Severe Mental Illness from Electronic Health Records.” ABSTRACT:Electronic Health Records (EHRs) offer an exciting avenue for large-scale genetic studies of psychiatric disorders in globally diverse populations. As […]

TITLE: "Population structure inference for biobank-scale data." ABSTRACT: Inferring the structure of human populations from genetic variation data is a key task in population and medical genomic studies. While a […]

Associate Professor of Genetics and of Computer Science, Yale School of Medicine “TBD” Hosted by Jason Ernst