TITLE: "Multimodal Single-Cell Epigenomic Sequencing of the Developing Human Cerebral Cortex." ABSTRACT: Single cell epigenomic technologies allow the measurement of unique molecular signatures within cells, however cell type complexity remains highly enigmatic. Emerging methods have enabled multiple modalities of epigenomic sequencing to be gathered from the same cell. Single-nucleus methyl-3C sequencing (sn-m3C-seq) delivers the capacity to […]

TITLE: "moPepGen: a fast custom database generator from multi-omics data for proteogenomics." ABSTRACT: Cancers are driven by genomic variants such as SNV (single nucleotide variants) and INDEL, often accompanied by many transcriptional variants. Modern mass spectrometry based proteomics is able to identify and quantify peptides and proteins comprehensively, however the variant-harboring peptides that are absent […]

TITLE: "Automated genetic analysis" Hosted by Nandita Garud.

TITLE: "Genomics for precision public health in Colombia" Hosted by Juan De La Hoz.

TITLE: "G-Flux: a metabolic flux and free energy analysis software for interpreting 13C, 2H, 18O, and 15N isotope tracing data." ABSTRACT: Metabolic fluxes offer insights into pathway utilization, kinetics, and thermodynamics. Stable isotope tracing and metabolic footprinting are widely used for inferring metabolic fluxes. However, quantitative flux measurement across broad metabolism remains challenging due to […]

TITLE: "PCA outperforms popular hidden variable inference methods for QTL mapping." ABSTRACT: Estimating and accounting for hidden variables is widely practiced as an important step in quantitative trait locus (QTL) analysis for improving the power of QTL identification. However, few benchmark studies have been performed to evaluate the efficacy of the various methods developed for […]

TITLE: "Stochastic Model and Optimization of SELEX." ABSTRACT: Systematic Evolution of Ligands by EXponential enrichment (SELEX) is a process to select the best aptamer sequence in a huge aptamer library that binds a specified target molecule with the highest affinity. There has been a deterministic model of SELEX, and we develop a fully discrete stochastic […]

TITLE: "Tensor Factorization for Interpreting the Mechanisms of MRSA Persistence." ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) bacteria is an increasingly common and life-threatening infection. While some antibiotics resolve MRSA infections in vitro, these same antibiotics often fail to clear an infection when used to treat patients, suggesting that MRSA persistence is a confluence of both host […]

TITLE: "Baseline MEthylation Patterns prior to flu vaccination." ABSTRACT: Influenza affects millions worldwide each year with responses varying from individual to individual. Influenza can be broken down into subtypes specifically H1N1, H3N2, Yamagata, and Victoria. One way to measure the immune response to influenza is to measure a person’s antibody response to influenza. To measure how […]

TITLE: "Universal annotation of the human genome through integration of over a thousand epigenomic datasets." ABSTRACT: Genome-wide maps of chromatin marks such as histone modifications and open chromatin sites provide valuable information for annotating the non-coding genome, including identifying regulatory elements. Computational approaches such as ChromHMM have been applied to discover and annotate chromatin states […]