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QCBio Research Seminar: Dongyuan Song (Li JJ), Graduate Student in Bioinformatics

ZOOM CA, United States

TITLE: "scDesign3: an all-in-one statistical framework that generates realistic single-cell omics data and infers cell heterogeneity structure." ABSTRACT: The generation of realistic synthetic data is essential for benchmarking numerous computation tools developed for single-cell omics data. Here we propose an all-in-one statistical framework that generates single-cell omics data from various cell heterogeneity structures, including discrete cell […]

QCBio Research Seminar: Xinzhou Ge (Li JJ), Postdoc in Statistics

ZOOM CA, United States

TITLE: "P-value-free solution to fix exaggerated false positives by popular differential expression methods." ABSTRACT: We report a surprising phenomenon that popular bioinformatics methods for identifying differentially expressed genes (DEG) between two conditions have unexpectedly high false discovery rates (FDRs) on large-sample-size RNA-seq datasets. Failed FDR control is likely due to the invalid p-values which rely on […]

W10: Mathematical Modeling of Cell Signaling

529 Boyer Hall 611 Charles E Young Dr E,, Los Angeles, CA, United States

Molecular biology has taught us a great deal about what is happening inside a cell, that is that pathways can get very complicated and life is not just independent pathways but networks. Fortunately, we can use computational tools to understand dynamics of complex networks. This workshop introduces the basic concepts of modeling cell signaling pathways. […]

QCBio Research Seminar: Apeksha Singh (Hoffmann), Graduate Student in Biomathematics

ZOOM CA, United States

TITLE: "Characterizing distinct cell states based on stimulus-response dynamics." ABSTRACT: Macrophages show remarkable functional pleiotropy that is dependent on microenvironmental context. Prior studies have characterized how polarizing cytokines alter epigenetic or signaling mechanisms, but how they affect specific macrophage functions has not been characterized systematically. One hallmark function of macrophages is to mount immune-threat appropriate […]

QCBio Research Seminar: Richard Law (Park), Graduate Student in Chemical and Biomolecular Engineering

ZOOM CA, United States

TITLE: "Quantitative flux analysis reveals redistribution of glycolytic pathways in dynamic nutrient environments." ABSTRACT: Optimal operation of metabolic fluxes is critical for an organism to be evolutionarily competitive. Textbook glycolysis is a conserved pathway that optimally utilizes carbohydrates for growth. However, it is unclear why some organisms simultaneously possess the parallel Entner-Doudoroff (ED) pathway, which […]