Events for March 5, 2021 - November 13, 2020

"Shrinkage-based random local clocks with scalable inference"

"MsCAVIAR: Identifying Causal Variants by Fine Mapping Across Multiple Studies"

TITLE: "Chemical reactions and condensates" ABSTRACT: In the past decade, condensates have been implicated as a mechanism of organization in biological systems. In addition to the potentially biologically relevant aspects of this, it has also encouraged physicists to revisit some aspects of the classic theories of phase separation, but now with inclusion of elements that more […]

TITLE: "Merging Experimental and Computational Approaches to Study Neurodegenerative Disease Dynamics" ABSTRACT: Neurodegenerative diseases such as Alzheimer's and Parkinson's affect millions of people around the world and are a growing health concern in aging populations. A major roadblock in developing effective treatments involve the diverse etiology and progression rates, combined with a lack of clear […]

TITLE: "Symmetry breaking during morphogenesis of a mechanosensory organ" ABSTRACT: The development of mechanosensory epithelia, such as those of the auditory and vestibular systems, results in the precise orientation of mechanosensory hair cells and consequently directional sensitivity. After division of a precursor cell in the zebrafish lateral line, the daughter hair cells differentiate with opposite mechanical […]

TITLE: "Biologist, Know Thy Cells - A Colorful Barcoding Method to ID Cell Types, their Fate, and Decode Brainwide Communication" ABSTRACT: A major challenge in biological imaging is resolving cell identities. These are necessary for determining cell-specific protein expression and function, the effect of transcription factors on cell fate, and the contribution of individual neurons to […]

TITLE: "Enhancer Loss and Gene Dosage Sensitivity Drives a Human Craniofacial Disorder" ABSTRACT: In recent years, the importance of understanding the role of non-coding regulatory mutations in human disease has become increasingly apparent. This is illustrated by a hotspot of non-coding mutations at the far end of a large gene desert surrounding the SOX9 gene that […]

TITLE: “Merging Experimental and Computational Approaches to Study Neurodegenerative Disease Dynamics” ABSTRACT: "Neurodegenerative diseases such as Alzheimer's and Parkinson's affect millions of people around the world and are a growing health concern in aging populations. A major roadblock in developing effective treatments involve the diverse etiology and progression rates, combined with a lack of clear understanding of […]

TITLE: "A quantitative view of strategies to engineer cell-selective ligand binding" ABSTRACT: Selective binding to specific target cells is a critical property of many therapies. To enhance selectivity in specific situations, a series of new strategies have been proposed in the drug development literature, including affinity, valency, multi-specificity, and other alterations to target cell binding. […]

TITLE: "Organoid Maturation by Circadian Entrainment " ABSTRACT: Stem cell-derived tissues that recap endogenous physiology are key for regenerative medicine. Yet, most methods yield products that function like fetal, not adult tissues. Organoids are typically grown in constant environments, while our tissues mature along with behavioral cycles. I show that inducing circadian rhythms in pancreatic islet organoids, […]