Events for October 23, 2023 - July 14, 2023

TITLE: "A lack of distinct cellular identities in scRNA-seq data: revisiting Waddington’s landscape." ABSTRACT: Single-cell RNA sequencing is revolutionizing our understanding of development, differentiation and disease. Analysis of this data is often challenging, however, and tasks like clustering cells to uncover distinct cellular identities sometimes yields results that fail to align with existing biological knowledge. We analyzed […]

TITLE: "Single Cell Multiomics Integration to Understand Complex Diseases." ABSTRACT: Recent advances in single cell multiomics technologies such as single cell RNA-seq, single cell ATAC-seq, and spatial transcriptomics have brought enormous opportunities that enable our understanding of the molecular underpinnings of pathophysiology at a single cell or cell type resolution. However, integrative analysis across single […]

TITLE: "Liquid Biopsies for Precision Oncology." ABSTRACT: Liquid biopsies are new diagnostic approaches to profile molecular features of solid tumors by blood, saliva, urine, and other body fluids. Such approaches offer non-invasive options in early cancer detection, tumor sampling, continuous monitoring, and designing personalized therapeutic options. Therefore, liquid biopsies have the potential to transform the […]

TITLE: "Building a tooth from transcriptome to tissue morphogenesis" ABSTRACT: During craniofacial development, the oral epithelium begins as a morphologically homogeneous tissue that gives rise to locally complex structures, including the teeth, salivary glands, and taste buds. How the epithelium is initially patterned and later shaped to generate diverse organ and cell types remains largely […]

TITLE: “Inducible plasmid copy number control and a blueprint for a synthetic genetic feedback optimizer” ABSTRACT: The ability to control gene expression has been paradigm shifting for all areas of biological research, especially for synthetic biology. This talk will focus on two recent advancements in gene expression control. First, TULIP (TUnable Ligand Inducible Plasmid) is presented: a self-contained plasmid with inducible copy […]