QCBio Research Seminar: Brian Orcutt-Jahns (Meyer)
ZOOM CA, United StatesTITLE: "A simple, two-step, multivalent binding model predicts IL-2 mutein cell signaling profiles." ABSTRACT: The common γ-chain cytokines are promising immune therapies, but have been limited in their efficacy due to their induction of non-specific immune activation. Here, we visualized immune cell response to both mono- and multivalent γ-chain muteins using a structured dimensionality reduction scheme. […]