TITLE: "Phenotypic consequences of gene expression variability." ABSTRACT: The central dogma of biology proposes that information flows from genes to RNA to protein, determining protein identity and abundance. Single cell […]
TITLE: "scDesign3: an all-in-one statistical framework that generates realistic single-cell omics data and infers cell heterogeneity structure." ABSTRACT: The generation of realistic synthetic data is essential for benchmarking numerous computation tools […]
TITLE: "Deriving network parameters for understanding drug effects.” Hosted by Jason Ernst.
TITLE: “The new forensic genetics: 'long-range' search and genetic privacy.” Hosted by Nandita Garud.
TITLE: "P-value-free solution to fix exaggerated false positives by popular differential expression methods." ABSTRACT: We report a surprising phenomenon that popular bioinformatics methods for identifying differentially expressed genes (DEG) between […]
TITLE: "Cellular plasticity in Cancer." Hosted by Jason Ernst.
Molecular biology has taught us a great deal about what is happening inside a cell, that is that pathways can get very complicated and life is not just independent pathways […]
TITLE: "Characterizing distinct cell states based on stimulus-response dynamics." ABSTRACT: Macrophages show remarkable functional pleiotropy that is dependent on microenvironmental context. Prior studies have characterized how polarizing cytokines alter epigenetic […]
TITLE: "Quantitative flux analysis reveals redistribution of glycolytic pathways in dynamic nutrient environments." ABSTRACT: Optimal operation of metabolic fluxes is critical for an organism to be evolutionarily competitive. Textbook glycolysis […]
