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QCBio/BIG Summer Research Seminar: Dr. Harold Pimentel, Assistant Professor in Computational Medicine & Human Genetics, UCLA

Boyer 159 611 Charles E. Young Dr. E., Los Angeles, CA, United States

TITLE: "Model driven design and analysis of functional screens" ABSTRACT: A little over a decade ago biomedicine was revolutionized by a conceptually simple insight: DNA sequencers could be used as molecular counting machines to measure a multitude of molecules beyond DNA. Through the years, sequencing has continued to become cheaper and more efficient (faster than […]

QCBio/BIG Summer Research Seminar: Dr. Nandita Garud, Assistant Professor Assistant Professor, Department of Ecology and Evolutionary Biology, UCLA

Boyer 159 611 Charles E. Young Dr. E., Los Angeles, CA, United States

TITLE: "Evolutionary dynamics in the human gut microbiome from infancy through adulthood." ABSTRACT: While the ecological dynamics of the infant gut microbiome have been intensely studied, relatively little is known about the evolutionary dynamics in the infant gut microbiome. Here we analyze longitudinal fecal metagenomic data from >700 infants and their mothers over the first […]

QCBio/BIG Summer Research Seminar: Dr. Eric Deeds, Associate Professor – Vice Chair, Life Sciences Core, UCLA

Boyer Hall 159

TITLE: "A lack of distinct cellular identities in scRNA-seq data: revisiting Waddington’s landscape". ABSTRACT: Single-cell RNA sequencing is revolutionizing our understanding of development, differentiation and disease. Analysis of this data is often challenging, however, and tasks like clustering cells to uncover distinct cellular identities sometimes yields results that fail to align with existing biological knowledge. We analyzed publicly available data where […]

QCBio/BIG Summer Research Seminar: Dr. Eleazar Eskin, Professor and Chair Department of Computational Medicine, UCLA

529 Boyer Hall 611 Charles E Young Dr E,, Los Angeles, CA, United States

TITLE: "Swab-Seq: Detecting COVID-19 with Genomic Sequencing: From bench to vending machine." ABSTRACT: At UCLA we developed one of the only novel technologies for COVID-19 diagnostic testing that was deployed on a large scale.  The assay, which we named SwabSeq, performs genomic sequencing of pooled samples tagged with sample-specific molecular barcodes and then uses computational […]

QCBio/BIG Summer Research Seminar: Dr. Xia Yang, Professor, Dept. Integrative Biology & Physiology, UCLA

Boyer 159 611 Charles E. Young Dr. E., Los Angeles, CA, United States

TITLE: “Integrative systems analysis, applications, and challenges of single cell multiomics.” ABSTRACT: Recent advances in single cell multiomics technologies such as single cell RNA-seq, single cell ATAC-seq, and spatial transcriptomics have brought enormous opportunities that enable our understanding of the molecular underpinnings of pathophysiology at a single cell resolution. However, integrative analysis across single cell […]

QCBio/BIG Summer Research Seminar: Dr. Michael Wells, Assistant Professor, Human Genetics, UCLA

Boyer 159

TITLE:  "Exploration of human genetic and phenotypic diversity through cell villages". ABSTRACT: Our species is characterized by an immense diversity in neurological and psychological traits. Common and rare genetic variants have been linked to trait differences and disease risk in human populations, though the underlying biology is poorly understood and difficult to study at large scales. […]

W22: Intro to Cytoscape

529 Boyer Hall 611 Charles E Young Dr E,, Los Angeles, CA, United States

The workshop introduces Cytoscape (https://cytoscape.org/) – an open source platform for retrieval and visualization of complex biological interactions that are available from public interaction resources: The IMEx Consortium (https://www.imexconsortium.org/), STRING (https://string-db.org/) and BioGIRD (https://thebiogrid.org/). It covers querying for interactions data using built-in search interface, interaction data cleanup and visualization as well as overlying of the […]

W4: Galaxy for NGS Data Analysis

529 Boyer Hall 611 Charles E Young Dr E,, Los Angeles, CA, United States

Galaxy (https://usegalaxy.org/) is a web-based infrastructure for bioinformatics application. First, this workshop introduces participants to using Galaxy for analysis of Next-Generation Sequencing data. Next, this workshop covers the structure of Galaxy, data format and manipulation, obtaining and sharing data, and building and sharing workflows. We will use the tools installed on the UCLA galaxy to […]

W6: BS-DNA Methylation Analysis with Hoffman2 and R

529 Boyer Hall 611 Charles E Young Dr E,, Los Angeles, CA, United States

This workshop will introduce the basic principles of DNA methylation and briefly describe available methods for DNA methylation assessment, focusing on bisulfite sequencing (BS-Seq). We will cover the principles of BSseq preprocessing, alignment and methylation calling, differential methylation analysis, annotation and visualization. Attendees will have the opportunity to work on real DNA methylation data provided […]

QCBio Research Seminar: Matthew Soldano, Staff Research Associate for the Pellegrini Bioinformatic’s Lab

ZOOM CA, United States

TITLE: "Predicting Biological Aging from Epigenetics." ABSTRACT: Epigenetics are a proven measure of cellular health. Therefore, a field of research has emerged that utilizes epigenetics to measure, treat, and potentially reverse biological age in humans. Specifically, DNA methylation, responsible for cell differentiation and gene expression, has the potential to be a barcode for measuring biological […]