Calendar of Events

TITLE: “Applications of generalized additive models and copulas to single-cell RNAseq computational method development: PseudotimeDE and scDesign2” ABSTRACT: Part 1: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data To investigate molecular mechanisms underlying cell state changes, a crucial analysis is to identify differentially expressed (DE) genes […]

TITLE: “Integrating single cell omics and deep phenotype data to discover genes underlying cardiometabolic disorders” ABSTRACT: Obesity predisposes to cardiometabolic disorders (CMDs), such as type 2 diabetes, multiple dyslipidemias, and non-alcoholic fatty liver disease (NAFLD). We are interested in how cell-type level gene expression contributes to CMDs and impacts cross talk between cardiometabolic tissues. We […]

TITLE: "Is there a Quiescence Histone Code?" ABSTRACT: Many of the cells in our bodies are quiescent, that is, temporarily not dividing. Under certain physiological conditions such as during tissue repair and maintenance, quiescent cells receive the appropriate stimulus and are induced to enter the cell cycle. The ability of cells to successfully transition into and […]

TITLE: “Model driven design and analysis of quantitative phenotype screens” ABSTRACT: Increasingly, CRISPR screens are coupled with flow cytometry (FACS) to sort cells and quantify the impact of genetic perturbations on a continuous phenotype. While FACS provides much more quantitative information than simple survival screens, it introduces a number of experimental and statistical challenges. Furthermore, as experimentalists push […]

TITLE: “Salivary exRNA for Gastric Cancer Detection” ABSTRACT: Biomarkers are needed for non-invasive early detection of gastric cancer (GC). We investigated whether salivary extracellular RNA (exRNA) biomarkers can be used as an efficient and economical clinical evaluation tool for GC. Unstimulated whole saliva samples were prospectively collected from 294 subjects (163 GC and 131 non-GC controls) who underwent endoscopic evaluation at […]