TITLE: "Enhancer Loss and Gene Dosage Sensitivity Drives a Human Craniofacial Disorder" ABSTRACT: In recent years, the importance of understanding the role of non-coding regulatory mutations in human disease has become […]
TITLE: “Merging Experimental and Computational Approaches to Study Neurodegenerative Disease Dynamics” ABSTRACT: "Neurodegenerative diseases such as Alzheimer's and Parkinson's affect millions of people around the world and are a growing health concern […]
TITLE: "A quantitative view of strategies to engineer cell-selective ligand binding" ABSTRACT: Selective binding to specific target cells is a critical property of many therapies. To enhance selectivity in specific […]
TITLE: "Organoid Maturation by Circadian Entrainment " ABSTRACT: Stem cell-derived tissues that recap endogenous physiology are key for regenerative medicine. Yet, most methods yield products that function like fetal, not adult tissues. […]
TITLE: "Building an integrated framework for tissue morphogenesis with the zebrafish inner ear" ABSTRACT: How simple tissues give rise to geometrically complex organs with robust shapes and functions is a fundamental […]
TITLE: "Understanding how environmental cues regulate Neuro-Mesodermal progenitor cells in development and disease" ABSTRACT: The trunk and tail of vertebrates arise from the addition of mesodermal (i.e., muscle and vertebrae) and […]
TITLE: "Cellular plasticity and fate choices in developing tissues and single cancer cells" ABSTRACT: While cellular processes are often reproducible and precise, cells may also alter their molecular states and adopt […]
TITLE: "Exploration of human genetic and phenotypic diversity through cell villages" ABSTRACT: Our species is characterized by an immense diversity in neurological and psychological traits. Common and rare genetic variants have […]
TITLE: "Imaging-based genetic recording of developmental histories" ABSTRACT: Systems-level understanding of cell fate decisions has been hampered by limitations of the existing methods to capture developmental history of the cells. Synthetic […]
TITLE: "Genomewide supervised prediction of activating and repressive regions in over hundred cell and tissue types" ABSTRACT: While the vast majority of variants associated with common disease risk are distributed […]