TITLE: "Building an integrated framework for tissue morphogenesis with the zebrafish inner ear" ABSTRACT: How simple tissues give rise to geometrically complex organs with robust shapes and functions is a fundamental […]
TITLE: "Understanding how environmental cues regulate Neuro-Mesodermal progenitor cells in development and disease" ABSTRACT: The trunk and tail of vertebrates arise from the addition of mesodermal (i.e., muscle and vertebrae) and […]
TITLE: "Cellular plasticity and fate choices in developing tissues and single cancer cells" ABSTRACT: While cellular processes are often reproducible and precise, cells may also alter their molecular states and adopt […]
TITLE: "Exploration of human genetic and phenotypic diversity through cell villages" ABSTRACT: Our species is characterized by an immense diversity in neurological and psychological traits. Common and rare genetic variants have […]
TITLE: "Imaging-based genetic recording of developmental histories" ABSTRACT: Systems-level understanding of cell fate decisions has been hampered by limitations of the existing methods to capture developmental history of the cells. Synthetic […]
TITLE: "Genomewide supervised prediction of activating and repressive regions in over hundred cell and tissue types" ABSTRACT: While the vast majority of variants associated with common disease risk are distributed […]
TITLE: "XIST controls X chromosome dampening and autosomal genes in early human development" ABSTRACT: Female human pre-implantation embryos and naïve human pluripotent stem cells (hPSCs) equalize X-linked gene expression with males […]
TITLE: "Fast estimation of genetic correlation for Biobank-scale data" ABSTRACT: Genetic correlation is an important parameter in understanding the shared genetic basis across pairs of complex traits with applications ranging across […]
TITLE: "Determining mRNA nuclear export kinetics reveals a wide range of values associated with innate immune response genes" ABSTRACT: The abundance and stimulus-responsiveness of mature mRNA is known to be […]
TITLE: "Oncogenic alterations in the p53 pathway abolish oscillatory competence" ABSTRACT: The tumor suppressor p53 displays concentration oscillations in response to DNA damage, a behavior that has been suggested to […]